Abstract Background Characterization of breast cancer (BC) through the determination of conventional markers such as ER, PR, HER2, and Ki67 has been useful as a predictive and therapeutic tool.Also, assessment of tumor-infiltrating lymphocytes has been proposed as an important prognostic aspect to be considered in certain BC subtypes.However, there

Carmen Almansa,1 Christopher S Frampton,2 José Miguel Vela,1 Steve Whitelock,3 Carlos R Plata-Salamán4 1Esteve Pharmaceuticals, S.A., Parc Cientific Barcelona, Barcelona 08028, Spain; 2Rbar3 Ltd, Cambridge, UK; 3Mundipharma Research Ltd, Cambridge, UK; 4Esteve Pharmaceuticals, S.A., Torre Esteve, Barcelona 08038, S

This paper analyzes the development processes of the text on the narration of case facts until it finally be ascertained in trial.It is a subtle evolution process from evidence to the list of events and eventually to the factual text.It is Papar a complex task to distinguish the content that would be inexorable once being proved and to reach consen

ABSTRACT Intramuscular vaccination of mice with the naked pBI-11 DNA plasmid targeting E6 and E7 of HPV16 and HPV18 via a conventional syringe and needle generates human papillomavirus (HPV) antigen-specific CD8+ T cell-mediated immune responses and therapeutic effects against the TC-1 tumor model.However, delivery of DNA vaccines by this method is

Aiming at the serious effect of coverage hole caused by the poor deployment environment and the Organic Black Seed with Vitamin C limited energy of wireless sensor network (WSN) on network lifetime, an optimized and lightweight energy-efficient connected coverage heuristic (OECCH) algorithm is proposed.Armed with the analysis of the coverage contri